BEE&YOU Apibeauty Anti-aging Face Serum
BEE&YOU Anti-Wrinkle & Anti-aging Face Serum is mainly formulated with bee venom, hyaluronic acid, propolis extract, raw honey, plant extracts, glycerin and aqua. Contains no chemicals.
What is Bee Venom?
Bee Venom is a complex mixture of proteins and amino acids, enzymes, sugars, and lipids. Melittin, a polypeptide is a major component of venom, and in humans it has the effect of stimulating the adrenal cortex (part of the adrenal gland) to release cortisol, a hormone associated with reducing inflammations and healing responses. Bee venom has been widely used as a cosmetic ingredient (topical agent) for promoting skin regeneration or a treatment of certain epidermal conditions. Topical application of bee venom can be well tolerated in the human skin because it has exhibited no dermal irritation potential in scientific studies. Long-term treatment with bee venom-containing cosmetics is safe because the irritation potential of bee venom is negligible.
SKU: 152NLDKAYS
BEE&YOU Anti-Wrinkle & Anti-aging Face Serum is mainly formulated with bee venom, hyaluronic acid, propolis extract, raw honey, plant extracts, glycerin and aqua. Contains no chemicals.
What is Bee Venom?
Bee Venom is a complex mixture of proteins and amino acids, enzymes, sugars, and lipids. Melittin, a polypeptide is a major component of venom, and in humans it has the effect of stimulating the adrenal cortex (part of the adrenal gland) to release cortisol, a hormone associated with reducing inflammations and healing responses. Bee venom has been widely used as a cosmetic ingredient (topical agent) for promoting skin regeneration or a treatment of certain epidermal conditions. Topical application of bee venom can be well tolerated in the human skin because it has exhibited no dermal irritation potential in scientific studies. Long-term treatment with bee venom-containing cosmetics is safe because the irritation potential of bee venom is negligible.
Main Purpose of Use and Benefits:
POWERFUL 100% NATURAL FORMULA: Deeply penetrates within skin's surface and helps replenish dry skin, for radiant, younger-looking skin with Aqua, Glycerin, Raw Honey, Iris Florentina Root Extract, Myrtle Tree Leaves Extract, Laurel Leaf Extract, Kiwifruit Extract, Corn Starch, Beet Root Extract, Rosa Multiflora Fruit Extract, Hydroxyethyl cellulose, Hyaluronic Acid, Propolis Extract, Bee Venom.
REDUCES FINE LINES AND WRINKLES: While improving skin’s texture and radiance, reduces fine lines and wrinkles. In 1 week, visibly plumps for younger looking skin that feels firmer, more elastic, and radiant; Skin looks and feels dewy instantly and overtime.
MINIMIZE PORES & IMPROVES ELASTICITY: Minimizes pores over time for smoother skin & deep moisturizing. Improves the elasticity & tonicity of your skin and assists with firming and revitalizing your skin.
SOOTHES INFLAMED SKIN & BLEMISHES: Bee Venom helps to nourish, plump and firm the skin. Soothes inflamed skin while helping to heal blemishes along with bee propolis extract.
SUITABLE FOR EVERY SKIN TYPE: dry skin, oily skin, combination skin, sensitive skin, and mature skin.
Applications of Bee Venom in Skin Care
Shrinks Pores: Bee venom is the best solution for pores. Its astringent properties help in removing excess oil and fluid from both the pores of skin and its uppermost layers.
Relieves Inflammation: One of the most important benefits of Bee Venom is its powerful anti-inflammatory effects. The soothing Adolapin which bee venom houses, it can quickly reduce the burning, redness, and swelling on skin.
Minimizes Wrinkles: Bee venom is known for its wrinkle-eliminating properties. It helps in stimulating blood flow inside body which makes the blood easier to flow to the surface of the skin. This ease of blood flow stimulates both the collagen and elastin production. Aside from this, what’s unique about Bee Venom is its ability to strengthen tissues to be able to stop premature aging.
Fades Blemishes: Bee venom properties which smooth are wrinkles & frown lines and shrink pores are also the ones who help fade acne blemishes. It also contains a peptide known as Melittin. Melittin has anti-bacterial and antimicrobial effects which are useful in fighting against acne.
Relaxes Muscles: The Bee Venom is helpful in relaxing the muscles as it strengths collagen and elastin to remain taut.
Directions: Apply gently with your fingertips in the morning and in the night, with circular movements. Use with Anti-aging Eye Contour Serum and Anti-aging Face Cream for effective care of the whole face.
Table-1
| Major Compounds of Bee Venom | |
| Major Compounds of Bee Venom | Description |
| Melittin | It is the main component of Bee Venom which is a 26- residue peptide, accounting 40-60% of Venom’s composition. The peptide has carboxyl- terminal region which is hydrophilic in nature & is responsible for lytic action. The amino- terminal region is hydrophobic in nature with no lytic activity. |
| Apamin | It is an 18- amino acid peptide which contains two disulfide bridges. Apamin is the smallest neurotoxin in the Bee Venom. It constitutes about 2-3% dry weight of Bee Venom. |
| Adolapin | It is a polypeptide with 103 amino acids residue. It constitutes about 1% dry weight of Bee Venom. |
| Mast-Cell Degranulating (MCD) Peptide | The MCD peptide is also known as Peptide 401, which is a Bee Venom Polypeptide containing 22 amino acids which is similar to apamin structure where both of them contains two disulfide bonds. It constitutes about 2-3% dry weight of Bee Venom. The mast cell degranulating peptide echoes the biological action in histamine release from mast cells. |
| Phospholipase A2 (PLA2) | PLA2 is single polypeptide chain of about 128 amino acids containing about four sulfide bridges. It is the most fatal enzyme in the Bee Venom. Bee Venom PLA2 is about 12-15% of Bee Venom’s dry weight & very alkaline in nature. |
| Hyaluronidase | Hyaluronidase is responsible to break down hyaluronic acid in tissues. It allows the active component of Bee Venom to effectively diffuse into the victim’s tissue, responsible to affect the structural integrity and thereby increase the blood flow in that area. These actions combine together & increase the spreading of venom. It constitutes about 1.5-2% of dry weight of Bee Venom. |
Table-2
| BEE&YOU Anti-aging Face Serum, 1.01 fl oz | ||
| Ingredients | Ingredient Description | Benefits |
| Aqua. | Water. | Moisturizer. |
| Glycerin. | Natural compound derived from vegetable oils. | Moisturizer. |
| Honey. | Natural honeybee product. | Antimicrobial, good for acne-prone ski, moisturizes the skin. |
| Iris Florentina Root Extract. | Extract of the roots of the Orris. | Inhibits the activity of enzymes causing the breakdown of proteins in the extracellular matrix (collagen and elastin) and favours the synthesis of DEJ (dermal-epidermal junction) anchor proteins. It reinforces the skin barrier and decreases the depth of wrinkles.. |
| Myrtus Communis Extract. | Evergreen shrub extract native to the Mediterranian region. | Increases cellular longevity and limit glycation. By limiting glycation, hydrolyzed Myrtus communis leaf extract helps the skin to maintain its strength and elasticity, resulting in a more youthful appearance.. |
| Laurus Nobilis Leaf Extract. | Extract of the leaves of the Laurel. | Antiseptic, antibacterial, and anti-fungal. Good for acne, inflamed skin and dandruff, but is also effective for healing of minor wounds.. |
| Hydrolized Corn Starch. | Natural absorbant corn starch. | Moisturizes the skin. |
| Beta Vulgaris Root Extract. | Beet Root Extract. | Skin conditioning. |
| Rosa Multiflora Fruit Extract. | Extract of the fruit of Rosa multiflora. | Masking, and tonic. |
| Hydroxyethylcellulose. | Natural gelling and thickening agent derived from cellulose. | Improves the texture and feel of the formulations. |
| Hyaluronic Acid. | Natural humectant. | Makes skin plumper, dewier and more hydrated, reduces the appearance of fine lines and wrinkles, speeds up wound healing. |
| Propolis Extract. | Extract of resin bee propolis. | Antioxidant and antimicrobial, good for acne-prone skin, reduces appereance of wrinkles and smooth out skin, recudes redness related to acne, allergies etc.. |
| Bee Venom. | Natural complex mixture of proteins and amino acids, enzymes, and lipids. | powerful anti-inflammatory and increases blood circulation, gently plumping out and firming the skin, filling and smoothing fine lines and wrinkles. |
- • Total experience of our founders about bees and bee products are more than 45 years. We are the experts in the field, especially about determination of quality and authenticity of bee products.
- • We develop all formulations in our R&D Center with contributions of pharmacologists, pharmacists, nutritionists, and dermatologists.
- • Our propolis extraction technology is patented worldwide, and we guarantee to provide the highest quality propolis extract with clinically proven health benefits.
- • We produce all our bee products with the help of our 5000 contracted beekeepers who take care of 550,000 beehives. We implement sustainable contracted beekeeping model as a perfect example of Fair Trade. That is how we can guarantee the best quality bee products with %100 traceability from our hives to your table.
- • We produce all our products at our facilities, which is about 10,500 m2, being one of the largest value-added bee products center worldwide.
- • Our facilities and products are certified against international standards both for food, supplements and cosmetics which are GMP, BRC, IFS, SEDEX, ISO 9000, ISO 22000, ISO 14001, Kosher, Cosmos and Organic.
- • We have been granted with 70 awards in the last 10 years for innovation, product quality, woman entrepreneurship and sustainability projects.
- • We aim to increase the bee population in the world: %1 of all the income gained from sales of each Bee&You product goes back to our beekeepers as new beehives so that they can look after more bees!
The above-listed effects were observed by healthy volunteers aged 33-70 who used this product for three weeks in a dermatological panel test. No irritation or allergenic reaction was observed by 15 volunteers, over 30 years old with sensitive skin, who used the products for three weeks in a dermatological patch test.
Yeditepe University (YÜ – AGAM, Istanbul, Turkey) carried out both tests.
Clinical Studies
Vitiligo: It is an abnormal pigmentation which is characterized by depigmentation of skin and hair. This is because of melanocyte proliferation, melanogenesis, and migration or increases in dendricity. As reported by Jeon et al. bee venom treatment elevates the melanocyte proliferation about two times as compared to the control in 1 week. By application of bee venom, the expression of MITF-M protein increases to the maximum level on third day and slowly decreases till fifth day. Bee venom treatment increases the ratio of cells with more than two dendrites by 23% in a time-dependent manner. The results showed that by bee venom treatment, the number of migrated cells as compared to the controls increases. It also induced melanocyte dendricity and melanocyte migration. The in-vitro study of bee venom has a positive effect on melanocyte proliferation, melanogenesis, dendricity, and migration. Thus, for treatment of vitiligo by repigmenting the skin, bee venom can be useful.
Facial Wrinkles: The beneficial effects of serum containing bee venom on facial wrinkles was studied by several scientific research where the application of bee venom serum resulted in decreased average wrinkle depth, total wrinkle area and count. It was also reported that the topical application of bee venom is safe for human use. Studies that were conducted on animals showed that it was well tolerated by them, and no dermal irritation was seen. Thus, application of bee venom is effective in improving the skin wrinkles thereby increasing the production of collagen and elastin.
Acne: As reported by Han et al. they performed a randomized double blind control trail where the therapeutic effects of bee venom on acne was examined. Subjective evaluation was done where bee venom on acne was applied by skin care products which contain bee venom and also products which do not contain bee venom for a period of 2 weeks. The results showed that the subjects that were applied cosmetics containing bee venom relatively showed a reduction by 57.5% in ATP levels, by the count of inflammatory & non-inflammatory lesions compared to the control, thereby measuring a decrease in the count of microbes. Therefore, Han et al. suggested that cosmetic containing bee venom is a good component as a therapeutic agent for acne.
Atopic Dermatitis: It is a type of skin disorder usually characterized by a defective skin barrier, drying of the skin, pruritus, eczema and also by some allergic responses. It is a chronic, inflammatory skin disorder which may worsen if not treated properly. Bee Venom because of its anti-inflammatory mechanism, it can be useful for treating atopic dermatitis. As reported by You et al. they did evaluation of about 136 subjects which were random distribution in different groups. Some subjects were applied bee venom containing moisturizer and silk protein and moisturizer without bee venom for a period of 4 weeks. The results indicates that application of the moisturizer with bee venom showed significantly lower eczema area and severity index and visual analogue scale, value compared to the patients who applied moisturizer without bee venom. There were as such no outstanding differences in the incidence of side effects induced by bee venom on the subject’s skin.
What to expect?
